<p><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:12px;">Summary of Position: Conducting research guided by the specific aims of the funding R01, focused on the development and application of assays for high-throughput screening (HTS) targeting ryanodine receptor calcium release channels (RyR).<br /><br />Develop and apply biophysical methods for structural and functional analysis of the RyRs in order to carry out HTS campaigns of RyR and the appropriate follow-up assays of identified compounds of interest. Publish papers in scientific journals based on own work. Represent lab and present own work at scientific meetings. Assist in the training and supervision of technicians, undergraduate and graduate students.<br /><br />Essential and Other Functions:<br />60% Structural and functional analysis of the ryanodine receptor calcium release channels (RyR)<br />Coordinate and lead translational research projects involving the development and application of biophysical methods for structural and functional analysis of the RyRs and their implementation for drug discovery.<br /><br />30% Publications and funding<br />Writes papers based on own work for publication in scientific journals, and presents this work at national and international scientific meetings. Assist the PI (Dr. Cornea) in writing grant applications.<br /><br />10% Mentorship<br />Assist in the training and supervision of technicians, undergraduate and graduate students in the laboratory.</span></span></p>
<p><span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">Required Qualifications:<br />• PhD in biochemistry, biophysics, physics, or chemistry plus 5 years of research experience.<br />• Strong publication record (at least five principal-author publications).<br />• 5 years of demonstrated experience in protein purification and spectroscopic labeling.<br />• 5 years of demonstrated experience with electron paramagnetic resonance and fluorescence spectroscopy.<br /><br />Preferred Qualifications:<br />Demonstrated experience with stopped-flow technologies.</span></span></p>
Internal Number: 325445
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